Active and inactive renin after captopril (SQ 14225) administration in hypertensive patients.
نویسندگان
چکیده
منابع مشابه
Haemodynamics of orally-active converting enzyme inhibitor (SQ 14225) in hypertensive patients.
1. The haemodynamic effects of oral converting enzyme inhibitor (SQ 14225) were assessed in eight patients with severe essential or renovascular hypertension. 2. Mean arterial pressure fell (149 +/- 5 to 127 +/- 8 mmHg, P less than 0.02), because of a fall in total peripheral resistance (6.9 +/- 0.53 to 5.7 +/- 0.40 kPa 1(-1)s m2) without a significant change in cardiac index. Two of the eight ...
متن کاملAltered blood pressure and renin responses to converting enzyme inhibition after aprotinin-induced kallikrein-kinin-system blockade.
1. The effect of aprotinin-induced blockade of the kallikrein-kinin system on haemodynamic and biochemical responses to converting enzyme inhibition by SQ 14 225 was evaluated in 26 patients with essential hypertension. 2. SQ 14 225 lowered blood pressure in high, normal and low renin hypertension. In low and normal renin patients, but not in high renin patients, the acute blood pressure-loweri...
متن کاملDynamic responses of active and inactive renin in patients with essential and renovascular hypertension.
We studied the dynamic responses of inactive renin and the form of renin released by the kidney in the hypertensive patients. Significant increase of active renin concentration (p less than 0.01) and decrease of the percentage of inactive renin concentration (p less than 0.01) after sodium depletion was observed in 15 essential hypertensive subjects with normal plasma renin activity. In eight o...
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We studied the relative rates of release of active and inactive renin by the kidney in anesthetized pigs. Renin concentration was determined in arterial and renal venous plasma as follows: (1) before and after stimulation of renin release with isoproterenol or furosemide, (2) after suppression of renin release by extracellular fluid volume expansion, and (3) after administration of propranolol ...
متن کاملAcute reduction in inactive renin after stimulation of active renin by converting enzyme inhibition (CEI) in man
1. Administration of a single dose of captopril, 50 mg, to normal man (n = 7) on a low salt intake induced a 12-5 f 0.9-fold rise in active renin. The rise in active renin was associated with a reciprocal decrease in circulating inactive renin to 1096 or less of control levels. 2. Repeated administration of captopril (50 mg p.0. q 6 h x 3 days) to normal man resulted in increases in both active...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1983
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.139.103